Fas, also known as APO?1 or CD95, belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. All appear to block the extrinsic apoptosis pathway induced by the Fas ligand (FasL, TNFSF6), a type II transmembrane protein of the TNF family that can be expressed on activated T?lymphocytes, NK cells and cells in immune privileged sites, or shed in soluble form. Engagement of FAS induces oligomerization of preformed Fas trimers. The activated receptor recruits the adaptor molecule FADD to form the Death?Inducing Signaling Complex (DISC). Upon activation, caspases in the DISC initiate the apoptotic signaling cascade. Fas is prominent in epithelial cells, hepatocytes, activated mature lymphocytes, virus-transformed lymphocytes and tumor cells. It is an essential mediator in the activation?induced death of T lymphocytes that terminates the immune reaction. In immune?privileged tissues, infiltrating Fas?bearing lymphocytes and inflammatory cells are killed by FasL engagement. Both humans and mice with genetic defects in Fas accumulate abnormal lymphocytes and develop systemic autoimmunity. The Fas pathway also appears to cross?communicate with the BIM (mitochondrial/intrinsic) apoptosis pathway.

產品性質

運輸與保存方法

冰袋運輸。-20℃至-80℃保存，一年有效期。

復溶后，-20 至 -80°C，在未開封狀態下保存 3-6 個月。復溶后，2-8°C 保存 2-7 天。

建議第一次使用時分裝凍存，避免反復凍融。

注意事項

1. 避免反復凍融。

2. 為了您的安全和健康，請穿實驗服并戴一次性手套操作。

3. 本產品僅作科研用途！

產品數據

HB220810