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Recombinant Human PD-L1/B7-H1(His Tag)

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翌圣生物科技(上海)股份有限公司更新時間：2024-12-24 09:03:45

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詳細介紹

PD-L1, also known as B7-H1, PDL1, is one of the ligands for PD-1 and plays a critical role in the regulation of T cell immunity. The PD-L1 protein is an approximately 65 kDa transmembrane glycoprotein belonging to the B7 family of immune regulatory molecules. Mature human PD-L1 protein consists of a 220 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 31 aa cytoplasmic domain. Within the ECD, human PD-L1 shares 73% and 74% aa sequence identity with mouse and rat B7-H1, respectively. PD-L1 provides a molecular stop signal to the adaptive immune system helping to distinguish between self and foreign antigens. PD-L1 also plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development.

產品性質

別名（Synonyms）	CD274, PDL1, PD-L1B7 homolog 1, B7-H, B7H1, B7-H1, PDCD1L1, PDCD1LG1
Uniprot No.	Q9NZQ7-1
表達區間及表達系統（Source）	HEK293 Cells-derived Human PD-L1 / B7-H1 Protein, Phe19-Arg238 with His tag at the C-terminal
分子量(Molecular Weight)	Approximately 26.0 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Tris-Bis PAGE result.
外觀(Physical Appearance）	Sterile Filtered White lyophilized (freeze-dried) powder.
純度（Purity）	> 95% as determined by SDS-PAGE and HPLC
活性（Activity）	ELISA Data: Immobilized Human PD-L1, His Tag at 0.5 μg/mL (100 μL/Well). Dose response curve for Anti-PD-L1 Ab., hFc Tag with the EC₅₀ of 6.1 ng/mL determined by ELISA.
內毒素（Endotoxin）	< 1.0 EU per 1μg of the protein by the LAL method.
制劑（Formulation）	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.
復溶（Reconstitution）	Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL` is recommended (usually we use 1mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.